Space is not a pleasant place. All that airless emptiness, broken up by things like clouds of flaming plasma and sentient space beings the size of planets that would like nothing more than snacking on a passing ship. As a result, the lives of space explorers aren't all sunshine, roses, and space blasters.
That's a good thing, because in Gloom, outer-space misery loves company. Put your Characters through the interstellar wringer before they come to an ignominious end, and win the game!
Gloom in Space can be played alone or combined with Gloom second edition and its expansions.